New Sneak Peek Signals Final Climax of Grey’s Anatomy Season 21

With Grey’s Anatomy taking a short break this week — there was no new episode or rerun due to the 2025 NFL draft — ABC is teasing the next episode of the show, which starts to count down to the season finale in mid-May. In a new sneak peek, viewers are presented with a case that will probably stretch for the remainder of the season. Amelia (Caterina Scorsone) will be at the center of it, and we will discover details of the case next Thursday, May 1.

The next episode, titled “Papa Was a Rollin’ Stone,” will introduce Yellowstone’s Piper Perabo to the cast. The newcomer is slated for a three-episode arc, and knowing that Grey’s Anatomy cases don’t tend to stretch over multiple episodes, we just know it will be a big and difficult one. In the sneak peek, Amelia is saying that she will have to take a “high-risk” approach to a nine-year-old girl’s angioma. Despite her years of experience, you can see that the case will be a big challenge for the doctor.

Amelia isn’t the only one that will have a hard time this week. The sneak peek also hints at Winston (Anthony Hill) and Jules (Adelaide Kane) in complete disagreement over how they should handle the family of a trauma patient. Aside from that, the episode will start preparing fans for one of the big events of the season: Jo (Camilla Luddington) and Link (Chris Carmack) are ready to tie the knot, even though the wedding planning doesn’t go as smoothly as they wish it would.

Is ‘Grey’s Anatomy’ Renewed For Season 22?

Regardless of what happens in the final stretch of episodes from Season 21, Grey’s Anatomy fans can relax knowing that another season is already on the way. ABC renewed the series earlier this month, and showrunner Meg Marinis already stated that title character Meredith Grey (Ellen Pompeo) is slated to return once again. At this point, we still don’t know the circumstances of her return, but Marinis is optimistic the former protagonist will come back for another seven-episode arc.

Aside from Perabo, the next episode of Grey’s Anatomy will also feature guest stars Brady Smith (That’s Funny), Cher Alvarez (NCIS: Hawai’i), Gabriel Sousa (Westworld), Andy Bean (Malignant), Sophia Kopera (Bosch: Legacy) and Natalie Morales (Summer of 69).

 

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